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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GSK3A All Species: 18.79
Human Site: S65 Identified Species: 29.52
UniProt: P49840 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49840 NP_063937.2 483 50981 S65 G G V G A S S S G G G P G G S
Chimpanzee Pan troglodytes XP_530044 483 51007 S65 G G V G A S S S G G G P G G S
Rhesus Macaque Macaca mulatta XP_001104964 483 50993 S65 G G V G A S S S G G G P G G S
Dog Lupus familis XP_852706 441 48143 L52 V T T V V A T L G Q G P E R S
Cat Felis silvestris
Mouse Mus musculus Q2NL51 490 51642 S65 G G V G A S S S G G G P S G S
Rat Rattus norvegicus P18265 483 51008 S65 G G V G A S S S G G G P S G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416557 433 48108 G45 T T V V A T P G Q G P D R P Q
Frog Xenopus laevis NP_001083752 420 46885 R30 F G S M K V S R D K D G S K V
Zebra Danio Brachydanio rerio NP_001038386 462 50821 A63 A A V V G S N A G K P G V S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P18431 1067 114422 G553 D A D S D G S G E N V K T A K
Honey Bee Apis mellifera XP_392504 434 48445 V46 K D R D G N K V T T V V A T P
Nematode Worm Caenorhab. elegans Q9U2Q9 362 40864
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VZD5 410 46056 S20 A T K Q S N A S I C A E K L P
Baker's Yeast Sacchar. cerevisiae P38615 370 42986
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 99.7 85.5 N.A. 93.8 97 N.A. N.A. 67.9 67.4 71.8 N.A. 33.4 64.1 55.2 N.A.
Protein Similarity: 100 99.7 99.7 86.3 N.A. 95.5 97.7 N.A. N.A. 74.9 74.5 77.6 N.A. 38 75.1 63.7 N.A.
P-Site Identity: 100 100 100 26.6 N.A. 93.3 93.3 N.A. N.A. 20 13.3 20 N.A. 6.6 0 0 N.A.
P-Site Similarity: 100 100 100 40 N.A. 93.3 93.3 N.A. N.A. 26.6 13.3 33.3 N.A. 6.6 6.6 0 N.A.
Percent
Protein Identity: N.A. 24.4 N.A. 52.8 40.7 N.A.
Protein Similarity: N.A. 38.1 N.A. 63.7 55.4 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 0 N.A.
P-Site Similarity: N.A. 0 N.A. 26.6 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 14 0 0 40 7 7 7 0 0 7 0 7 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 7 7 7 7 7 0 0 0 7 0 7 7 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 7 0 0 7 7 0 0 % E
% Phe: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 34 40 0 34 14 7 0 14 47 40 40 14 20 34 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % I
% Lys: 7 0 7 0 7 0 7 0 0 14 0 7 7 7 7 % K
% Leu: 0 0 0 0 0 0 0 7 0 0 0 0 0 7 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 14 7 0 0 7 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 7 0 0 0 14 40 0 7 14 % P
% Gln: 0 0 0 7 0 0 0 0 7 7 0 0 0 0 14 % Q
% Arg: 0 0 7 0 0 0 0 7 0 0 0 0 7 7 0 % R
% Ser: 0 0 7 7 7 40 47 40 0 0 0 0 20 7 40 % S
% Thr: 7 20 7 0 0 7 7 0 7 7 0 0 7 7 0 % T
% Val: 7 0 47 20 7 7 0 7 0 0 14 7 7 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _